2014 Fiscal Year Final Research Report
Studies about a clinically usable radiosensitizer - PARP inihibitor
| Project/Area Number |
25861114
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
HORI Masakazu 札幌医科大学, 医学部, 助教 (90404714)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 放射線治療 |
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| Outline of Final Research Achievements |
Olaparip, a PARP inhibitor had the radiosensitizing effects in as low concentrations as 0.05μM, that is clinically attainable. In esophageal cancer, the higher expression of XRCC4 indicated the significantly deteriorated local control and overall survival, suggesting that the inhibition of DNA repair may be effective to improve treatments results of esophageal cancer. Olaparib could be promising in the treatment of esophageal cancer as a radionsensitizer. Further researches are required.
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| Free Research Field |
医歯学
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