Development of the novel method for the early diagnosis of Alzheimer's disease using high-resolution diffusion tensor imaging at 7 Tesla MRI

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861119
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Iwate Medical University
• Principal Investigator: Ito Kenji 岩手医科大学, 医学部, 助教 (80646852)
• Research Collaborator: SASAKI Makoto ; TERAYAMA Yasuo
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 拡散MRI / 軽度認知障害 / アルツハイマー病 / パーキンソン症候群 / 早期鑑別診断

Outline of Final Research Achievements

High-resolution 3-Tesla diffusion tensor imaging analysis was able to detect substantial changes in diffusion anisotropy and diffusivity in the parahippocampal cingulum bundle of patients with mid cognitive impairment (MCI) who were destined to convert to Alzheimer’s disease (AD). Our method may prove effective for the early diagnosis of patients with MCI who will eventually convert to AD. Moreover, we developed high-resolution 7-Tesla diffusion tensor imaging based on the reduced field of view. The combination of our method and the multiband acceleration in the slice direction can be used to establish the innovative imaging technique for the early diagnosis of patients with MCI.

Free Research Field

放射線科学