2015 Fiscal Year Final Research Report
Biological optimization for brachytherapy combined with external beam radiation therapy
| Project/Area Number |
25861124
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
YOROZU Atsunori
OHASHI Toshio
HANADA Takashi
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 小線源治療 / 外照射 / 最適化 |
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| Outline of Final Research Achievements |
We demonstrated generalized equivalent uniform doses (gEUD) to be a potential predictive factor for grade 2+ late rectal bleeding after I-125 prostate brachytherapy combined with external beam radiation therapy. We tested the NTCP model suggested by the QUANTEC review (quantitative analysis of normal tissue effects in the clinic) of late rectal bleeding dose-volume factors: the Lyman-Kutcher-Burman (LKB) model, using gEUD. This study calculated NTCP parameter values for late rectal bleeding observed in combined therapy.
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| Free Research Field |
放射線治療
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