2015 Fiscal Year Final Research Report
Control of viscosity of Lipiodol and development of low-viscosity oily contrast media
| Project/Area Number |
25861129
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Tokai University (2015)
Nippon Medical School (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 放射線医学 / 血管内治療 / 肝細胞がん / 肝動脈化学塞栓術 / リピオドール / NBCA |
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| Outline of Final Research Achievements |
As in vitro study, we evaluated the influence of temperature on the viscosity of mixtures with different NBCA-Lipiodol concentration. In the result, warming of the mixture decreases the viscosity and the higher concentration of NBCA within the mixture make the viscosity lower.
As in vivo study, we performed transcatheter arterial embolization of renal arteries of rabbits using NBCA-Lipiodol mixtures with various temperatures (3, 20 and 50 degrees) and concentrations (50, 33, 25 % of NBCA). Then, the difference of the distribution of NBCA-Lipiodol mixture within the renal artery was histopathologically evaluated using Oil Red staining. In the result, the mixture with the lower viscosity tends to distribute in the renal arteries with the smaller diameters.
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| Free Research Field |
放射線医学
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