2014 Fiscal Year Final Research Report
E ffect of antii TNF-a antibody against colon cancer : Does anti TNF-a antibody inhibits growth of colon cancer?
| Project/Area Number |
25861169
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
HANEDA Sho 東北大学, 医学(系)研究科(研究院), 大学院非常勤講師 (20436140)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | Crohn's disease / anti TNF-a / colon cancer |
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| Outline of Final Research Achievements |
[Background and Aim] The risk of incidence of colorectal cancer in Crohn's disease is high. On the other hand, TNF-a inhibitors are frequently used for the treatment of Crohn's disease. There may be a risks for cancer emergence by using anti TNF-a drugs, but it is still controversial. The aim of the present study was to investigate the effect of anti TNF-a antibody for growth of colorectal cancer.
[Materials and Method] We used colon cancer cell lines (COLO205, DLD1, HCT8, HCT116, HT29) and stimulate those cells with TNF-a, anti TNF-a antibody. Proliferation was determined by using CCK-8 assay.
[Results and Conclusions] TNF-a reduced growth of colon cancer cells, while blockage of TNF-a by anti TNF-a antibody reduced progression of colon cancer cells. Thus, TNF-a plays a profound role in malignancy of colorectal cancer, and inhibition of TNF-a represents a promising therapeutic option.
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| Free Research Field |
下部消化管
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