2015 Fiscal Year Final Research Report
The role of CGRP in regulation of colonic motility and defecation
| Project/Area Number |
25861170
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
ONO Tomoyuki
SHIBUYA Emiko
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | GMC / CGRP / 排便 |
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| Outline of Final Research Achievements |
We measured colonic motility to analyze the effect of intravenous administration of CGRP(calcitonin gene-related peptide) in conscious dogs. Intravenous administration of CGRP induced giant migrating contraction and defecation in colon. The frequency of the contractions increased dose-dependently. The results suggest that intravenous administration of CGRP may induce the colonic motility and defecation. Besides, the result may contribute to the development of the new laxative which has less side effects and can be administered intravenously.
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| Free Research Field |
消化器外科学
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