2014 Fiscal Year Final Research Report
Development of drug eluting biodegradable extravascular stent to prevent vein graft failure
Project/Area Number |
25861224
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular surgery
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Keywords | 冠動脈バイパス術 / 生体吸収性薬物徐放血管外ステント / ラパマイシン / 静脈グラフト / 新生内膜 / コンプライアンスミスマッチ |
Outline of Final Research Achievements |
Vein graft stenosis and occlusion at long term have been a significant clinical issue. We tested the hypothesis that drug eluting biodegradable extravascular stent can prevent vein graft stenosis by suppressing an increase in the hemodynamic stress and also by inhibiting excessive cellular proliferation. We developed rapamycin (RM) eluting biodegradable poly L-lactic acid and epsilon-caprolactone copolymer (PLA-CL) extravascular stent.Femoral vein graft interposition was performed in beagles. Beagles were divided into four groups: without a stent (control); with a PLA-CL stent only; and with a PLA-CL stent containing RM 80 μg, and with 800 μg. Pathohistologic analyses were performed at 12-month interval. Rapamycin eluting biodegradable extravascular stent can modify the long-term deterioration of vein graft compliance. In addition, the drug eluting extravascular stent can inhibit neointimal hyperplasia of vein grafts and prevent graft stenosis at long term.
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Free Research Field |
心臓血管外科 虚血性心疾患 成人心臓血管外科
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