2014 Fiscal Year Final Research Report
Establishment of novel lung SCC model using deltaNp63 inducible system
| Project/Area Number |
25861248
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory surgery
|
|---|
| Research Institution | Osaka City University |
|---|
Principal Investigator |
YAMANO Shotaro 大阪市立大学, 医学(系)研究科(研究院), 助教 (80614528)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | deltaNp63 / TET/On / lung |
|---|
| Outline of Final Research Achievements |
【Objective】In this study, we challenged the establishment of novel mice model of lung Squamous cell carcinoma (SCC) using lung epithelium specific deltaNp63 inducible system and evaluated the role of deltaNp63 positive cancer cells in the lung SCC of the peripheral type. 【Results】We could not succeed the establishment of novel mice model of lung SCC. Nevertheless, we clearly observed that deltaNp63 positive cancer cells were co-expressed CD44v, Ki67 and P-Stat3 proteins and tumor associated macrophages (TAMs) were increasing near these cells. These data indicated that TAMs might be needed for deltaNp63 positive cancer cells monoclonal expansions and the formation of the tumor microenvironment in lung SCC.
|
| Free Research Field |
実験病理学
|
