2015 Fiscal Year Final Research Report
The mechanism of accumlation of tracer for FMT-PET in malignant brain tumors
| Project/Area Number |
25861256
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | University of the Ryukyus (2014-2015)
Gunma University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 神経膠腫 / PET検査 / L型アミノ酸トランスポーター |
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| Outline of Final Research Achievements |
Usefulness of positron emission tomography with amino acid tracer FMT(FMT-PET) for diagnosis of malignant brain tumors and the mechanism of its specific accumulation in tumor tissues were analyzed. FMT-PET was considered useful for diagnosis of WHO grade (malignancy) and histological type in glioma. In addition, system L type neutral amino acid transporter LAT-1 were highly expressed in tumor cells and tumor vessel endothelial cells in immunohistochemical study. Because the intensity of LAT-1 expression was significantly correlated with WHO grade(malignancy), suggested that accumulation of FMT to tumor tissues may be strongly involved by the intensity of LAT-1 expression.
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| Free Research Field |
脳神経外科
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