Biomarkers associated with malignant transformation in grade II and III gliomas

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861268
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Nagoya University
• Principal Investigator: MOTOMURA Kazuya 名古屋大学, 医学(系)研究科(研究院), 特任准教授 (30467295)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: グリオーマ / 悪性転化

Outline of Final Research Achievements

Grade II and III gliomas are slowly progressing brain cancers, many of which eventually transform into more aggressive tumors.　Grade II and III gliomas comprise three distinct subtypes characterized by discrete sets of mutations and distinct clinical behaviors. Mutations showed significant positive and negative correlations and a chronological hierarchy, as inferred from different allelic burdens among coexisting mutations, suggesting that there is functional interplay between the mutations that drive clonal selection.

Free Research Field

脳腫瘍