Analysis of Homeobox genes and specific peptide for molecular therapy in Glioblastoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861269
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Nagoya University
• Principal Investigator: HASEGAWA Hitoki 名古屋大学, 医学(系)研究科(研究院), 研究員 (10454381)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 神経膠芽腫 / ホメオボックス / Notch / PRRX1

Outline of Final Research Achievements

The expression levels of PRRX1 mRNA were increased in most of the low grade and high-grade glioma samples when compared to the levels in the normal brain tissues. The depression of PRRX1 suppressed the invasion and neurosphere formation of glioblastoma cells. We also found specific activation of the Notch pathway in PRRX1-expressing cells. Consistent with the activation of Notch signaling, increased levels of HES1 mRNA and protein by PRRX1 expression were observed. We found a correlation between PRRX1 and HES1. Our results indicate that the activation of Notch signaling by PRRX1 is associated with the promotion of glioblastoma cell invasion and tumorigenicity.

Free Research Field

腫瘍生物学