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2015 Fiscal Year Final Research Report

Correlation between cell cycle and chemotherapy resistance and lung metastases - Analysis using Fucci transfected sarcoma cells

Research Project

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Project/Area Number 25861301
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionNagoya City University (2014-2015)
Kanazawa University (2013)

Principal Investigator

KIMRA HIROAKI  名古屋市立大学, 医学(系)研究科(研究院), 助教 (50608693)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywords細胞周期 / イメージング / 骨肉腫 / 化学療法 / 紫外線
Outline of Final Research Achievements

we utilized the fluorescence ubiquitination-based cell cycle indicator (FUCCI) imaging system to investigate the correlation between cell-cycle behavior and apoptosis after treatment of osteosarcoma cells with chemotherapeutic drugs.
Osteosarcoma cell line 143B expressing FUCCI were treated with doxorubicin or cisplatinum, and we revealed that apoptosis behavior, cell cycle arrest, and chemotherapy sensitivity depending on cell cycle differs in each chemotherapy drugs.

Free Research Field

骨軟部腫瘍

URL: 

Published: 2017-05-10  

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