2015 Fiscal Year Final Research Report
Correlation between cell cycle and chemotherapy resistance and lung metastases - Analysis using Fucci transfected sarcoma cells
| Project/Area Number |
25861301
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nagoya City University (2014-2015)
Kanazawa University (2013) |
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Principal Investigator |
KIMRA HIROAKI 名古屋市立大学, 医学(系)研究科(研究院), 助教 (50608693)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 細胞周期 / イメージング / 骨肉腫 / 化学療法 / 紫外線 |
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| Outline of Final Research Achievements |
we utilized the fluorescence ubiquitination-based cell cycle indicator (FUCCI) imaging system to investigate the correlation between cell-cycle behavior and apoptosis after treatment of osteosarcoma cells with chemotherapeutic drugs.
Osteosarcoma cell line 143B expressing FUCCI were treated with doxorubicin or cisplatinum, and we revealed that apoptosis behavior, cell cycle arrest, and chemotherapy sensitivity depending on cell cycle differs in each chemotherapy drugs.
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| Free Research Field |
骨軟部腫瘍
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