Examination of the expression and localization of the Bone Morphogenetic proteins during peripheral nerve regeneration.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861312
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Mie University
• Principal Investigator: KOKUBU Naoki 三重大学, 医学部附属病院, 助教 (40632378)
• Co-Investigator(Renkei-kenkyūsha): TUJII Masaya 三重大学, 医学系研究科, 助教 (40444442) ; IINO Takahiro 三重大学, 医学系研究科, 技術補佐員 (80626119) ; SUDO Akihiro 三重大学, 医学系研究科, 教授 (60196904)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: BMP / 末梢神経再生 / Schwann cell

Outline of Final Research Achievements

The peripheral nerve injury made the significant up-regulation of BMP7/Smad signaling in the axon-Schwann cell units at the distal to the injured site. in vitro study demonstrated that cell viability of Schwann Cells(SCs) was significantly increased by administration of BMP7. Also by PTH(1-34) administration, electrophysiological studies showed the advantage of improvement of MCV after peripheral nerve injury. Furthermore, in vitro study, the Expression of BMP7 in SCs was significantly increased by administration of PTH(1-34).From these results, re-expressed BMP7/Smad signal can indirectly function in axonal regeneration as a neurotrophic growth factor for SCs, and suggested that PTH(1-34) is not only acting on bone metabolism, and is involved in peripheral nerve regeneration through SCs.

Free Research Field

末梢神経