2014 Fiscal Year Final Research Report
The effect of Vitamin D3 on the degradation of articular cartilage
| Project/Area Number |
25861336
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka City University |
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Principal Investigator |
OHTA Yoichi 大阪市立大学, 医学(系)研究科(研究院), 病院講師 (50633484)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 活性型ビタミンD3 / 関節軟骨 |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the effect of Vitamin D3 on the differentiation of chondrocytes and the degradation of articular cartilage. Primary mouse epiphyseal chondrocytes were isolated from new born mice, and subjected to gene expression analysis. Treatment with Vitamin D analog tended to stimulate Erg and lubricin (Prg4) expression. Local administration of Vitamin D analog to mice subjected to osteoarthritis (OA)-inducing surgery tended to decrease joint degradation following OA inducing surgery.
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| Free Research Field |
整形外科
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