2014 Fiscal Year Final Research Report
Analysis of molecular mechanisms maintaining homeostasis of intervertebal disc and leading to degeneration
| Project/Area Number |
25861337
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 椎間板 / 腰椎変性疾患 / 椎間板変性 |
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| Outline of Final Research Achievements |
The experiments described in this investigation demonstrated for the first time that in NP cells, expression of SDC4 was controlled by oxemic tension. Our studies also revealed that HIF-1alpha and not HIF-2 alpha controlled hypoxic regulation of SDC4 expression. A second major observation was that SDC4 modulated the expression of Sox9, a key transcriptional regulator of aggrecan expression in NP cells. These findings lend strong support to the hypothesis that in the hypoxic intervertebral disc, SDC4 is important in homeostatic maintenance of the NP.
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| Free Research Field |
整形外科
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