Approach from muscle to bone and cartilage regeneration and development of the treatment of diseases

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861347
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Kinki University
• Principal Investigator: YANO Masato 近畿大学, 医学部, 助教 (30500821)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 破骨細胞 / 筋芽細胞 / 異所性骨化 / 進行性骨化性線維異形成症 / TGF-β

Outline of Final Research Achievements

We investigated the role of osteoclasts during heterotopic bone formation in muscle tissue. The implantation of myoblasts with BMP-2 induced robust heterotopic ossification with an increase in the formation of osteoclasts in the muscle tissues than subcutaneous tissues. Moreover, the causal mutation transfection of fibrodysplasia ossification progressive in myoblasts enhanced the formation of osteoclasts through TGF-β in vivo and in vitro. This study demonstrated that the causal mutation transfection of fibrodysplasia ossification progressive in myoblasts enhances bone and cartilage regeneration through formation of osteoclasts from its precursor in muscle tissues.

Free Research Field

医歯薬学