2015 Fiscal Year Final Research Report
Elucidation and control of the inhibitor to myocardium protection under depressive state
| Project/Area Number |
25861380
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
ICHINOMIYA Taiga 長崎大学, 医歯薬学総合研究科(医学系), 助教 (50404249)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 薬理学的ポストコンディショニング |
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| Outline of Final Research Achievements |
It is thought that PI3K-Akt activity without JAK-STAT is important for myocardial protection against ischemic reperfusion injury under depressive state. In this study, it was found that fasudil hydrochloride which is Rho kinase inhibitor activates m-KATP channel without JAK-STAT, COX-2 and showed myocardial protection. Therefore, fasudil hydrochloride may show myocardial protection under depressed state.
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| Free Research Field |
医歯薬学
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