2016 Fiscal Year Final Research Report
The study to evaluate the effect of bumetanide on the effectiveness of anesthetic agents in the neonate
| Project/Area Number |
25861389
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Yokohama City University |
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Principal Investigator |
KARIYA TAKAYUKI 横浜市立大学, 附属市民総合医療センター, 助教 (90614404)
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|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 鎮静作用 / NKCC1 / KCC2 |
|---|
| Outline of Final Research Achievements |
Cl- transporters control intracellular Cl- concentration, which affects the behaviour of anesthetic agents. We examined if the activation of KCC2 enhances the sedative actions of midazolam. We revealed that CLP290, KCC2 enhancer via phosphorylation of KCC2, enhanced MDZ-dependent sedation.
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| Free Research Field |
麻酔薬
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