2015 Fiscal Year Final Research Report
Melatonin receptor agonist for the prevention of postoperative delirium
| Project/Area Number |
25861391
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | せん妄 / メラトニン / 高齢者 |
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| Outline of Final Research Achievements |
Melatonin is a hormone secreted by pineal gland. Melatonin regulates sleep-wake cycle and resets circadian rhythms. Ramelteon is the melatonin receptor 1 (MT1) agonist and used to sleep induction. The aim of our study was to evaluate whether the ramelteon could reduce the incidence of postoperative delirium and improve postoperative quality of recovery. Perioperative ramelteon showed the tendency to reduce the incidence of postoperative delirium, but not statistically significant. Further large randomized controlled trials are needed to assess ramelteon for the prevention of postoperative delirium in elderly patients during perioperative period.
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| Free Research Field |
集中治療医学
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