The mechanism of prostate cancer progression via the macrophage infiltration into prostate cancer microenvironment

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861413
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Kanazawa University
• Principal Investigator: IZUMI Kouji 金沢大学, 医学系, 特任助教 (80646787)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 前立腺癌 / 転移 / ケモカイン / マクロファージ

Outline of Final Research Achievements

Human prostate cancer cells with high metastatic ability can secrete more CCL2 than those with low metastatic ability and CCL2 can induce prostate cancer cell migration, regardless of the presence of the suppression of androgen/androgen receptor signal. In addition, CCL2 induce the infiltration of macrophages into prostate cancer tissue, and then chemokines secreted by infiltrated macrophages can induce prostate cancer migration.

Free Research Field

泌尿器腫瘍学