2014 Fiscal Year Final Research Report
Anti-inflammatory effect of intravenous injection of adipose-derived regenerative cells using a cystitis rat model
| Project/Area Number |
25861417
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 脂肪由来幹細胞 / 膀胱 / 炎症 / homing / ラット |
|---|
| Outline of Final Research Achievements |
We injected adipose-derived regenerative cells (ADRCs) via the tail vein using a cystitis rat model. Near-infrared light in vivo imaging showed "homing phenomenon" of ADRCs to the inflamed bladder. Pencil lens charge-coupled device microscopy showed increased microcirculation of the bladder wall in the ADRCs-injected rats. There were no obvious histological changes in the bladder, and a significant decrease of pro-inflammatory cytokines by ELISA. Cystometrogram revealed prolonged intercontraction intervals. Nociceptive behaviors decreased in the ADRCs-injected group. The results of this study indicated the possibility of intravenous injection of ADRCs as a new treatment for interstitial cystitis.
|
| Free Research Field |
排尿障害学
|
