2014 Fiscal Year Final Research Report
A study of the impact of chronic hypoxia has on the malignant transformation of prostate cancer cells
| Project/Area Number |
25861428
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 低酸素 / 前立腺癌 |
|---|
| Outline of Final Research Achievements |
This study showed that chronic hypoxia environment plays an important role in malignant transformation of prostate cancer (androgen-independent behavior and enhancement of proliferation and invasion), and was elucidate that mechanism.
By analyzing the chronic hypoxia-conditioned prostate cancer cells, we indicated that the chronic hypoxia involved in enhancement of cell invasiveness, change of intracellular signaling and gene expression. We analyzed candidate genes involved in malignant potential of prostate cancer, and showed the potential for new therapies.
|
| Free Research Field |
前立腺癌
|
