Development of crystal dissolve therapy by analyzing two macrophage phenotypes

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861443
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: Taguchi Kazumi 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (00595184)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 腎結石 / マクロファージ / 炎症 / Randall's plaque / マイクロアレイ / マルチプレックス解析

Outline of Final Research Achievements

In vivo study using stone model mice showed that renal crystal formation increased by M1Mφ treatment whereas decreased by M2Mφ treatment.
Urinary protein multiplex analysis demonstrated that the expression of IL-4, G-CSF, and IL-1a, which were associated with M2Mφ and neutrophil, was decreased in stone-patients.
Gene expression profile of renal papillary tissue by microarray analysis revealed that stone-patients had higher expression of M1Mφ-related genes but lower expression of M2Mφ-related genes.

Free Research Field

尿路結石