2014 Fiscal Year Final Research Report
Development of an in vitro culture methods for low quality embryos
| Project/Area Number |
25861479
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 胚培養 / メタボローム |
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| Outline of Final Research Achievements |
We are interested in developing a prophylactic method for oocyte aging.
To compare small molecule metabolites and embryo quality, we used embryos from C57BL/6J mice (as a model of high quality embryo) and DBA/2J mice (as a model of low quality embryo).
Our results showed that the amount of specific metabolites associated with amino acids contained in DBA/2J embryos are lower than the amount of metabolites contained in C57BL/6J embryos. Also we found that the developmental rate of DBA/2J embryos were improved using novel medium including these specific metabolites.
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| Free Research Field |
生殖工学
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