Genomic factor associated with HPV persistent infection

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861498
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Nagasaki University
• Principal Investigator: ABE Syuhei 長崎大学, 医歯薬学総合研究科(医学系), 助教 (50549590)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 子宮頸癌 / コピー数多型 / DEFB4 / HPV

Outline of Final Research Achievements

We obtained three heads of results in this study. (1) When considering the cervical cancer prevention and health check system in Japan, to clarify the HPV genotyping of the HPV16 and HPV52 is important. (2) HPV16 and/or 52 genotyping and viral load of cervical scraping cells are useful as a molecular marker to estimate the changes in the cervical cytology. (3) Latest knowledge of an association between cervical cancer and DEFB4 copy-number variation, it was considered useful for the diagnosis and prevention of the onset of cervical cancer.

This study now performs exsome analysis and methylation array analysis using the next-generation sequencing method is expected to be connected to the identification of more host side factors.

Free Research Field

産婦人科学