Search of a new vocal cord mucosa components by imaging mass spectrometry

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861553
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• Principal Investigator: KADA Shinpei 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (70543263)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 喉頭 / 声門下粘膜 / 質量顕微鏡 / コラーゲン / エラスチン

Outline of Final Research Achievements

Using mass microscope , we measured the lipid distribution of the human larynx . Previous studies revealed few constituents of such collagen and elastin in the submucosal tissue of the vocal cord. Now we revealed that the submucosal substance represents m / z 583.0 , m / z 605.0, and m / z 621.1 in the spectrum .
The substance identified by further mass microscope or these materials is what was done , it is not possible to obtain sufficient spectrum , until material identified did not reach . The cause is considered possible that the presence of the constituent materials is too small, in addition to the inadequate experimental conditions . In the future, only those portions make an integrated , we aim to elucidate the mass analysis .

Free Research Field

喉頭基礎