Curcumin suppresses replication of respiratory syncytial virus and release of inflammatory cytokines and chemokines in normal human nasal epithelial cells.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861573
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Sapporo Medical University
• Principal Investigator: OKUNI Tsuyoshi 札幌医科大学, 医学部, 助教 (40464490)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ヒト鼻粘膜上皮 / 呼吸器ウイルス

Outline of Final Research Achievements

Respiratory syncytial virus (RSV) is one of the most important pathogens for bronchitis, pneumoniae and asthma in infants and young childrens. However, an effective vaccine and anti-viral therapy for RSV infection have not yet been developed. RSV replicats in the airway mucosa, where it may produce umcomplicated upper respiratory infection or spread distally to lower airways, producing more sever lower respiratory tract infection. In this study, we showed that curcumin which has multipharmacological effects including inhibition of NF-kB activation, proteasome activation and elF2 alpha dephosphorylation prevented the replication of RSV in human nasal epithelial cells. Inhibition of RSV in HNECs by curcumin may be effective treatment and prevention for severe lower respiratory disease.

Free Research Field

ヒト鼻粘膜上皮における自然免疫