2014 Fiscal Year Final Research Report
Mechanisms of inflammsomes activation in human tonsil
| Project/Area Number |
25861575
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 口蓋扁桃 / 扁桃癌 / インフラマソーム |
|---|
| Outline of Final Research Achievements |
We found strong expression of NLRP3, ASC, IL-1β, IL-18, and Caspase-1 in human oropharyngeal SCC, while weak or no expression of these proteins in normal tonsil. We also found that the distribution of MIB-1 was not significantly different from inflammasome-associated proteins in oropharyngeal SCC, and that no correlation of the expression of inflammasome-associated proteins and HPV infection. These findings suggest that inflammasomes in oropharyngeal SCC have a key role through facilitating antitumor immunity, and the possibility of new roles for inflammasomes in oropharynx may exist.
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| Free Research Field |
耳鼻咽喉科学
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