2015 Fiscal Year Final Research Report
A novel regerative therapy for sensorineural hearing loss
Project/Area Number |
25861599
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
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Research Institution | Fujita Health University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 突発性難聴 / 内耳虚血 / 胚性細胞 / 骨髄由来間葉系幹細胞 / 再生医療 |
Outline of Final Research Achievements |
Sensory hair cells and auditory neurons do not regenerate throughout life, and loss of these cells is irreversible and cumulative. However recent advances in stem cell biology have provided hope that stem cell therapy will come closer to regenerating sensory hair cells and auditory neurons in humans. In the present study, we have investigated the effects of sodium valproate on the fate of embryonic stem cells. Consequently sodium valproate has clearly demonstrated to promote neurogenesis of ES cells. Thereafter we performed the comprehensive gene expression analysis of ES cells during differentiation into inner ear progenitor cells. Furthermore. to establish the methods for selecting inner ear progenitor cells exclusively, we have integrated GFP, a reporter gene, into the Tlx3 allele of the ES cell lines.
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Free Research Field |
耳鼻咽喉科学
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