2016 Fiscal Year Final Research Report
Histological Study of Costal Cartilage after Transplantation and Reasons for Avoidance of Postoperative Absorption and Retain Cartilage Structure in Animal model
| Project/Area Number |
25861712
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 軟骨移植 / 軟骨膜除去 / GFP transgenic rat / FIB/SEM tomography / 間葉系幹細胞 |
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| Outline of Final Research Achievements |
The sections of costal cartilage was harvested from 10-week-old wild rats and transplanted to dorsal region of 10-week-old green fluorescent protein (GFP) transgenic rat. These were subcutaneously harvested from GFP rats at 4-weekes and 8- weeks. This experiment was carried out in 2 randomized groups, with the perichondrium removed from the transplanted cartilage in one group, and with intact perichondrium transplanted. The GFP-positive chondrocytes in 8 weeks later in the group of the perichondrium removed. The GFP-positive chondrocytes was not replaced in the group of perichondrium intact. This result showed cartilage was reproduced from membrane-like tissue regenerated around cartilage after removing the perichondrium; continuously generating new chondrocytes.
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| Free Research Field |
形成外科
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