2014 Fiscal Year Final Research Report
Pharmacological Stabilization of Intracranial Aneurysms in Mice: A Feasibility Study
| Project/Area Number |
25861717
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
MAKINO HIROSHI 浜松医科大学, 医学部附属病院, 講師 (10397408)
|
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 脳動脈瘤 / 肥満細胞 / マウス |
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| Outline of Final Research Achievements |
In the animal model of abdominal aneurysm, inhibitor of releasing chemical mediator from the Mast cell prevented growth of abdominal aortic diameter. This feasibility study aimed to prevent intracranial aneurysm (IA) rupture using the inhibitor of releasing chemical mediator from the Mast cell. Our experiment revealed that inhibitor of releasing chemical mediator from the Mast cell prevented aneurysm rupture in our mouse model of IA. This result may implicate human IA treatment in future.
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| Free Research Field |
周術期管理医学
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