2014 Fiscal Year Final Research Report
The novel exploration of the factors for maintaining the function of ameloblasts and stratum intermedium during mouse enamel formation
| Project/Area Number |
25861741
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu Dental College (2014)
Niigata University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | エナメル質形成 / Msx2 / エナメル芽細胞 / エナメル器 / 外エナメル上皮 / 中間層細胞 |
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| Outline of Final Research Achievements |
It is important to elucidate the detailed mechanisms of normal tooth development to realize tooth regeneration in the future. We found that the outer enamel epithelium (OEE) became keratinized stratified squamous epithelium (SSE) during enamel formation in Msx2 knock-out mice leading to the loss of function of ameloblasts and subsequent enamel hypoplasia. Our data suggest that Msx2 plays a critical role for inhibiting the transformation of the OEE into keratinized SSE and it is essential to maintain the OEE for normal enamel formation.
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| Free Research Field |
発生学
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