The machanism of the regulation of FGF signaling by Runx2 in skeletal development

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861748
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Nagasaki University
• Principal Investigator: ROKUTANDA Satoshi 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (60549608)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 頭蓋縫合早期癒合 / 四肢形成異常 / Runx2 / FGFシグナル

Outline of Final Research Achievements

Gain of function mutations of fibroblast growth factor receptor (FGFR)1, FGFR2, FGFR3 cause craniosynostosis such as Apert, Crouzon, Pfeiffer, Muenke syndromes and Thanatophoric dysplasia. Further, Apert syndrome and Crouzon syndrome show limb defects. The mice, in which Runx2 was overexpressed in carvaria and limbs, showed craniosynostosis and limb defects. In the mice, FGF expression in limbs was abnormal, indicating that Runx2 is involved in the regulation of FGF signaling.

Free Research Field

口腔外科学