2014 Fiscal Year Final Research Report
The study of blood clotting and venous repair regulated by a novel protein
| Project/Area Number |
25861756
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
ASANO Satoshi 広島大学, 医歯薬保健学研究院(歯), 助教 (30570535)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 細胞移動 / PI3-kinase / 細胞骨格 / 創傷治癒 |
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| Outline of Final Research Achievements |
To repair damaged tissues, fibroblasts form lamellipodia at its leading edge and migrate to the damaged tissues, resulting in contribution of wound healing. The lamellipodia formation is regulated by the metabolism of PI(4,5)P2, an inositol phospholipid, into PI(3,4,5)P3. In this study, we revealed a possible regulatory mechanism by phospholipase C-related catalytically inactive protein (PRIP), an inositol phospholipid-binding partner, in PDGF-induced cell migration.
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| Free Research Field |
細胞生物学
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