2014 Fiscal Year Final Research Report
Analysis for the fuction of sweet receptor
| Project/Area Number |
25861759
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 味覚 / 甘味受容体 / 甘味抑制物質 / ギムネマ酸 |
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| Outline of Final Research Achievements |
Gymnemic acids (GAs) are triterpene glycosides that selectively suppress taste responses to various sweet substances without affecting salty, sour, and bitter compounds. To elucidate interaction between sweet receptor and GAs, we used the sweet receptor T1R2 + T1R3 assay in transiently transfected HEK293 cells. We found that interaction site for GAs was the transmembrane domain of hT1R3. Glucuronic acid, the common structure of gymnemic acids, also reduced sensitivity to sweet compounds, suggesting that the glucuronosyl group of GAs is required for sweet-suppressing effect.
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| Free Research Field |
医歯薬学
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