Breakthrough of fluoride-functional mechanism and establishment of its utilization for oral Actinomyces

2016 Fiscal Year Final Research Report

• Project/Area Number: 25861783
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Tohoku University
• Principal Investigator: Kawashima Junko 東北大学, 東北メディカル・メガバンク機構, 助教 (50633707)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: Actinomyces / Streptococcus / 根面齲蝕 / 糖代謝 / 重炭酸 / 歯学

Outline of Final Research Achievements

Both Streptococcus and Actinomyces can produce acids from dietary sugars and are frequently found in caries lesions. In addition to glycolysis (EMP pathway), Actinomyces species have a pathway that utilizes part of the tricarboxylic acid cycle to combine PEP (a metabolic intermediate of the EMP pathway) with bicarbonate to produce succinate. This study aimed to elucidate the effects of nitrogenous compounds on acid production. Tryptone enhanced glucose-derived acid production. Addition of glutamate increased glucose-derived acid production. These results suggest that nitrogenous compounds in the oral cavity promote acid production by Streptococcus and Actinomyces in vivo.

Free Research Field

口腔生化学