Bisphosphonates related osteonecrosis: Aim to elucidate and treatment mechanism

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861910
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Tohoku University
• Principal Investigator: Oizumi Takefumi 東北大学, 歯学研究科(研究院), 大学院非常勤講師 (40547262)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 顎骨壊死 / ビスフォスフォネート

Outline of Final Research Achievements

Bisphosphonates(BPs) agent with strong bone resorption inhibitory effect have been used for various enhanced bone-resorptive diseases. However, since BP-related osteonecrosis of the jaw (BRONJ), first reported in 2003, is increasing, with few effective strategies. BRONJ is exclusively associated with the use of nitrogen-containing BPs (NBPs). We previously reported that in mice, the non-NBP etidronate can reduce the inflammatory/necrotic effects of NBPs by inhibiting their intracellular entry and antagonize NBPs’ binding to bone hydroxyapatite absorption. We applied papers that the BRONJ 14 patients case and BRONJ patient of diabetes control bad case which tried to etidronate substitute replacement therapy of non-NBP.

Free Research Field

歯科