2015 Fiscal Year Final Research Report
The effects of neurotrophic factor in the orofacial neuropathic pain
| Project/Area Number |
25861936
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
Oyamaguchi Aiko 大阪大学, 歯学研究科(研究院), 助教 (70464237)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | C線維 / IB4 / c-Fos |
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| Outline of Final Research Achievements |
The functional significance of non-peptidergic C-fibers in orofacial pain processing is largely unknown. The present study examined the effects of the selective elimination of isolectin B4 (IB4) -binding (IB4+) neurons on formalin-induced face rubbing behavior (FRB) in the upper lip of rats and c-Fos-immunoreactive (c-Fos-IR) cells in the trigeminal subnucleus caudalis (Vc).
These results indicate that IB4+ neurons in the trigeminal nerve play antinociceptive regulatory roles in formalin-induced orofacial pain processing and that GABAA receptor functions at segmental and supratrigeminal sites have complex modulatory influences on antinociceptive roles.
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| Free Research Field |
口腔顔面痛
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