2014 Fiscal Year Final Research Report
Development of a new therapy by Knockdown of the Brachyury for oral cancer stem cells
| Project/Area Number |
25861958
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
|
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| Research Institution | Kyushu University |
|---|
Principal Investigator |
KOBAYASHI YOSUKE 九州大学, 歯学研究科(研究院), 研究員 (60636554)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | Brachyury / chemotherapy / radiation / cancer stem cell |
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| Outline of Final Research Achievements |
This study demonstrates that Brachyury knockdown reduces invasiveness and chemoresistance and radioresistance of Cancer stem cells in vivo. Therefore, Brachyury knockdown may be a useful therapeutic tool for sensitizing Cancer stem cells to conventional chemoradiotherapy.
|
| Free Research Field |
腫瘍
|
