The new treatment strategy for lymph node metastasis in oral squamous cell carcinoma - Targeting COX-2 and TAM

2016 Fiscal Year Final Research Report

• Project/Area Number: 25861978
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Tokyo Medical University
• Principal Investigator: Kono Michihide 東京医科大学, 医学部, 助教 (00421066)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 口腔癌 / リンパ節転移 / 腫瘍関連マクロファージ

Outline of Final Research Achievements

This study aimed to propose new treatment methodology for lymph node metastasis in oral squamous cell carcinoma(OSCC). Especially we focused on Tumor associated macrophage (M2 macrophage) in the tumor microenvironment in OSCC.Our data showed that M2 macrophage strong expression group was significantly related to locally progressive, lymph node metastasis, and prognosis. Moreover, this group showed the tendency that highly expression rate in COX-2 and VEGF-C.　In conclusion M2 macrophage in the tumor microenvironment in OSCC might be become the treatment target for prevent the locally progressive, lymph node metastasis.

Free Research Field

口腔癌