2014 Fiscal Year Final Research Report
Lung regeneration from iPS by using Nrf2 activator
Project/Area Number |
25870071
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General medical chemistry
Experimental pathology
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Research Institution | National Cancer Center Japan (2014) Tohoku University (2013) |
Principal Investigator |
SATOH Hironori 独立行政法人国立がん研究センター, 研究所, 特別研究員 (90407479)
|
Co-Investigator(Renkei-kenkyūsha) |
MORITA Masanobu 東北大学, 大学院医学系研究科・医化学分野, 助教 (10519094)
MORIGUCHI Takashi 東北大学, 大学院医学系研究科・医化学分野, 講師 (10447253)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Keywords | 肺再生 / Nrf2-Keap1 |
Outline of Final Research Achievements |
The field of lung development lags behind other tissues because of the complex tissue structure. The fact that Nrf2 could contribute to activation of lung developmental genes made us to analyze the relationship between Nrf2 (anti-oxidative stress gene) and lung development. In vivo lung regeneration experiment revealed that Nrf2 plays important roles in lung development. Given this, we next conducted in vitro studies using mouse pluripotent stem cells. Our results indicate that Nrf2 participates in lung development. Further studies are needed to apply this result to clinical use.
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Free Research Field |
呼吸器内科学、呼吸器腫瘍学
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