Lung regeneration from iPS by using Nrf2 activator

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870071
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry; Experimental pathology
• Research Institution: National Cancer Center Japan (2014); Tohoku University (2013)
• Principal Investigator: SATOH Hironori 独立行政法人国立がん研究センター, 研究所, 特別研究員 (90407479)
• Co-Investigator(Renkei-kenkyūsha): MORITA Masanobu 東北大学, 大学院医学系研究科・医化学分野, 助教 (10519094) ; MORIGUCHI Takashi 東北大学, 大学院医学系研究科・医化学分野, 講師 (10447253)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 肺再生 / Nrf2-Keap1

Outline of Final Research Achievements

The field of lung development lags behind other tissues because of the complex tissue structure. The fact that Nrf2 could contribute to activation of lung developmental genes made us to analyze the relationship between Nrf2 (anti-oxidative stress gene) and lung development. In vivo lung regeneration experiment revealed that Nrf2 plays important roles in lung development. Given this, we next conducted in vitro studies using mouse pluripotent stem cells. Our results indicate that Nrf2 participates in lung development. Further studies are needed to apply this result to clinical use.

Free Research Field

呼吸器内科学、呼吸器腫瘍学