Mechanisms of neurogenic bladder in neuropathic pain

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870073
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology; Urology
• Research Institution: Akita University
• Principal Investigator: YOSHIZUMI MASARU 秋田大学, 医学(系)研究科(研究院), 助教 (70553379)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: プロスタグランジン / ロキソプロフェン / グリシン / 排尿機能 / 脊髄 / グリシン受容体α3サブユニット

Outline of Final Research Achievements

We examined the inhibitory effects of loxoprofen, a cyclooxygenase inhibitor, and glycine, a major inhibitory neurotransmitter, on the micturition reflex in conscious rats and the involvement of crosstalk. With cystometry, intravenous or intrathecal injection of loxoprofen and glycine prolonged the intercontraction intervals (ICI) in conscious rats. The combination of loxoprofen and glycine prolonged the ICI more than with either drug alone. The inhibitory effects of glycine on the ICI prevented by GlyRα3-siRNA treatment. These results suggest that loxoprofen and glycine inhibits the afferent limbs of the micturition reflex pathway in the lumbosacral cord via cyclooxygenase inhibition and glycine receptor α3 subunit-mediated inhibition, respectively.

Free Research Field

神経生理