A better understanding of liver environmental factors on hematogenous metastasis.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870157
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry; Experimental pathology
• Research Institution: The University of Tokyo
• Principal Investigator: SAIJOU Eiko 東京大学, 分子細胞生物学研究所, 技術専門職員 (60376647)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 転移

Outline of Final Research Achievements

Liver is known as frequently hematogenous metastatic organ. To perform a detailed analysis of liver immune cells, colon cancer cell line Colon26 was transplanted subcutaneously into Balb/c mice. As a result of this transplantation, Ly6G positive neutophil migration was observed prior to liver metastasis of cancer cells. A quantitative RT-PCR experiment shows that significant over expression of chemokine KC in the liver. Liver metastasis was reduced by subcutaneous cancer transplant by using via spleen metastasis model. Immuno-depletion of neutrophil significantly enhances liver metastasis by using via spleen metastasis model. These results indicate that neutrophil plays inhibitory role on colon cancer liver metastasis.

Free Research Field

疾患生物学