2014 Fiscal Year Final Research Report
Search for new risk gene for chronic hepatitis B
Project/Area Number |
25870178
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
Medical genome science
|
Research Institution | The University of Tokyo |
Principal Investigator |
SAWAI Hiromi 東京大学, 医学(系)研究科(研究院), 特任助教 (60377124)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Keywords | 肝臓学 / B型肝炎 / 疾患関連遺伝子 |
Outline of Final Research Achievements |
We performed trans-ethnic association analyses of HLA-DPA1, HLA-DPB1 alleles and their haplotypes with hepatitis B virus infection and healthy control samples among Asian populations comprising Japanese, Korean, Hong Kong, and Thai subjects. Association analyses identified a new risk allele HLA-DPB1*09:01, and new protective alleles DPB1*02:01 and DPB1*04:01 to chronic HBV infection in addition to the previously reported alleles. Moreover, to identify new host genetic factors contributing to HBV infection, we conducted genome-wide association study (GWAS) and replication analyses using Japanese, Korean, Hong Kong, and Thai individuals. We unfortunately did not replicate the GWAS result although we could identify 529 SNPs with P < 10-4 in the GWAS stage.
|
Free Research Field |
ゲノム医学
|