Analysis of calcium homeostasis of endolymph in the cochlea.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870248
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology; Otorhinolaryngology
• Research Institution: Niigata University
• Principal Investigator: NIN Fumiaki 新潟大学, 医歯学系, 准教授 (80644905)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: カルシウム / イオン輸送 / 内リンパ液電位 / 血管条

Outline of Final Research Achievements

In order to reveal the mechanism of calcium transport in the cochlea of the inner ear, we used double -barreled ion-selective electrode which can measure the calcium concentration and potential at the same time. We inserted the electrode into the cochlear lateral wall and then measure the change of calcium and potential in vivo under anoxic condition. Calcium concentration in the intrastrial space of the lateral wall increase after the onset of anoxia. When we release the perturbation, calcium concentration decreased and returned to the normal level. The previous study reported that the calcium concentration in endolymph increases under anoxic condition, therefore, these results indicates that the calcium unidirectional transport from endolymph to the lateral wall is endowed in the cochlea.

Free Research Field

聴覚生理学