2015 Fiscal Year Final Research Report
Elucidation of regulation mechanisms of RP105/MD-1 in obesity-induced chronic inflammation
| Project/Area Number |
25870257
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Metabolomics
Immunology
|
|---|
| Research Institution | University of Toyama |
|---|
Principal Investigator |
WATANABE Yasuharu 富山大学, 大学院医学薬学研究部(医学), 客員助教 (80646307)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 炎症 / 内臓脂肪組織 |
|---|
| Outline of Final Research Achievements |
The RP105/MD-1 complex expressing cells in hematopoietic cells were involved in high-fat diet-induced adipose tissue inflammation. We found that levels of soluble MD-1 in mice serum were increased by high-fat diet. Soluble MD-1 was dramatically increased by high-fat diet in visceral adipose tissue and produced from stromal vascular cells in the tissue. Soluble MD-1 was increased in co-culture of macrophages and adipocytes, suggesting that macrophages produce soluble MD-1 by the interaction with adipocytes. We identified several candidate lipids from lipid library, which interact with MD-1.
|
| Free Research Field |
免疫学
|
