Elucidating the intracellular molecular mechanisms of cell death of cancer cells by atmospheric pressure plasma

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870307
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plasma electronics; Tumor biology
• Research Institution: Nagoya University
• Principal Investigator: TANAKA Hiromasa 名古屋大学, 未来社会創造機構, 講師 (00508129)
• Co-Investigator(Renkei-kenkyūsha): ISHIKAWA Kenji 名古屋大学, プラズマナノ工学研究センター, 特任教授 (60417384) ; NAKAMURA Kae 名古屋大学, 大学院医学系研究科, 特任講師 (10744047)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: プラズマがん治療

Outline of Final Research Achievements

We found that plasma-irradiated medium induced apoptosis on glioblastoma brain tumor cells, and termed this medium plasma-activated medium (PAM). PAM down-regulated activities of signaling molecules in the survival and proliferation signaling network and induced reactive oxygen species (ROS) on glioblastoma to induce apoptosis. The PAM projects have brought us many collaborative works that include collaborations with departments of Obsterics and gynecology, Gastrointestinal surgery for treatments of peritoneal dissemination of ovarian cancers and gastric cancers, and Ophthalmology for treatments of age-related macular degeneration. We have published 10 papers and applied for 9 patents.

Free Research Field

プラズマ医療