regulation mechanism of metabolism and aging via p38 signal in blood cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870328
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry; Immunology
• Research Institution: Mie University
• Principal Investigator: Ookuma Sadatusgu 三重大学, 医学(系)研究科(研究院), 助教 (70444429)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: メタボリックシンドローム / MAPキナーゼ

Outline of Final Research Achievements

We produced hematopoetic cells specific and macrophage specific p38 alpha KO mice, and examined high-fat diet induced metabolic syndrome. We found that high-fat diet induced obesity and hyperglycemia are suppressed in these mutants. And we tested diet-induced NASH model, and found that inflammation and fibrosis is suppressed in macrophage specific p38 alpha KO mice. We are now trying to produce premature aging p38 alpha KO mice. We have preliminary adminstered p38 inhibitor to premature aging model mice, and observed prolonged lifespan of them.

Free Research Field

生化学