2014 Fiscal Year Final Research Report
The roles of osteocalcin in the relationships among bone, adipose tissue, and muscle.
Project/Area Number |
25870449
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Endocrinology
Orthopaedic surgery
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Research Institution | Shimane University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Keywords | オステオカルシン / 脂肪細胞 |
Outline of Final Research Achievements |
The expressions of osteocalcin and its receptor, GPRC6A, were found in preadipocytic 3T3-L1 cells. Osteocalcin expression was decreased during the differentiation of 3T3-L1 cells, while GPRC6A expression was increased. Although osteocalcin decreased the expression of C/EBPβ and PPARγ, carboxylated and uncarboxylated osteocalcin did not affect the size of adipocytes by Oil red O staining. On the other hand, both osteocalcin inhibited the proliferation of 3T3-L1 cells, suggesting that osteocalcin may suppress the accumulation of fat mass.
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Free Research Field |
内分泌代謝
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