Prion protein overexpress induces on autophagy mechanism explication.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870474
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry; Neurology
• Research Institution: The University of Tokushima
• Principal Investigator: YANO Masashi 徳島大学, 疾患酵素学研究センター, 技術員 (10531858)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: プリオン / オートファジー

Outline of Final Research Achievements

Prion is the disease to which neurodegeneration death happens by surplus accumulation of prion protein. The mechanism of this nerve cell death is unclear, but participation of apoptosis through autophagy is advocated. In this study, I worked on mechanism of activation of the autophagy which happens by the thing which makes a HEK293T cells protein overexpress. It's analyzed using a prion model mice whether this mechanism by HEK293T cells participates in nerve cell death of prion.

Free Research Field

プリオン